For the first time, genes chemically silenced by stress during life have been shown to remain silenced in eggs and sperm, allowing the effect to be passed down to the next generation.
The finding, obtained from detailed DNA scans in developing mouse eggs and sperm, backs up mounting indirect evidence from statistical studies that the genetic impacts of environmental factors such as smoking, diet, stressed childhoods, famine and psychiatric disease can be passed down to future generations through a process called epigenetic inheritance. Many geneticists had considered this an impossibility.
Genes can be switched off by altering DNA through a chemical process called methylation, in which enzymes respond to environmental factors by marking genes with methyl groups that prevent them from working.
But the idea that genes carrying these epigenetic markings could be inherited is controversial. Previous studies had shown that as sperm and eggs develop, any markings added to genes during life are erased to provide a genetic "blank slate" from which the next generation develops. Any remaining marks were also thought to be erased when an egg is fertilised.
Now a team led by Jamie Hackett at the University of Cambridge has challenged this picture. The researchers extracted the DNA from mouse primordial germ cells ? the precursors to sperm and eggs ? at various stages of their development and used markers to spot any methylated genes.
They found that a tiny number of methylated gene regions survived unerased: an average of just 233 out of approximately 25,000 in the germ cells examined. Still, the work clearly shows that traits resulting from the surviving markings can potentially be passed on. "What we've found is a potential way things can get through, whereas before, everything was considered to be erased," says Hackett.
Unresolved issue
Do the markings survive simply because the erasure process may not always work properly, or are they deliberately spared so that the information they carry is passed to the next generation? The finding "doesn't solve this question", says Hackett. "But it's a proof of principle for one possible mechanism by which traits might be inherited epigenetically."
Those sceptical of epigenetic inheritance are adamant that even if some methylated DNA makes it through, it is likely to be because of faulty erasure. "The idea that what's left carries information about the environment is sufficiently far-fetched to demand much more evidence of its importance," says Adrian Bird of the University of Edinburgh, UK. "I'd say [the erasure] is an inefficient process, and what's left doesn't matter."
Researchers who claim to have demonstrated that epigenetic traits can be passed down were more enthusiastic. Isabelle Mansuy of the Swiss Federal Institute of Technology in Zurich has found that in mice, the effects of stress in infancy can be passed from one generation to at least the next two. "The paper demonstrates there are regions which do escape reprogramming," she says. "This is fundamental to the idea of epigenetic inheritance of acquired traits that so many people are reluctant to accept, because it does indicate that it is possible to maintain some marks intact from parents to offspring."
Hackett says that he and his colleagues plan to repeat the experiment in human cells, and that they hope to resolve the question of whether some genes escape demethylation through luck or design.
Journal reference: Science, doi.org/kbj
If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.
Have your say
Only subscribers may leave comments on this article. Please log in.
Only personal subscribers may leave comments on this article
Subscribe now to comment.
All comments should respect the New Scientist House Rules. If you think a particular comment breaks these rules then please use the "Report" link in that comment to report it to us.
If you are having a technical problem posting a comment, please contact technical support.
Outback Bowl Carly Rae Jepsen dallas cowboys Rose Bowl 2013 kim kardashian anderson cooper kim kardashian pregnant
কোন মন্তব্য নেই:
একটি মন্তব্য পোস্ট করুন